Table II

Table II: Patients at risk for cardiovascular
disease have high ADMA levels

ADMA	Carotid % occlusion	Hcys	BS	CRPHS	Cholesterol	Age	Patient
mM	Rt and Lt	mM	Mg/dL	Mg/L	Mg/dL		Gender

0.2	24 26	13.9	110	2.59	204	70	male
0.23	22 30	12.74	86	9.57	172	65	female
0.43	30 30	10.05	93	1.73	213	68	female
0.5	12 18	14.12	90	3.06	165	59	male
0.55	38 33	5.47	92	2.64	180	72	male
0.59	25 33	5.19	131	0.52	135	80	male
0.6	55 25	10.1	91	3.07	188	66	female
0.7	10 14	10.6	93	2.34	175	50	female
0.7	23 27	7.28	115	5.78	256	61	female
0.8	70 75	6.5	101	0.77	138	65	male
0.8	50 75	10.7	90	3.37	135	72	male
0.84	68 54	9.28	108	13.65	157	72	male
0.85	26 35	7.33	81	2.01	92	77	female
0.86	22 60	7.38	90	2.54	173	58	male
0.9	70 75	4.45	83	1.38	171	52	female
0.94	60 80	8.28	112	2.2	138	86	male
0.94	14 17	4.4	80	4.26	196	54	female
0.95	30 38	7.7	135	1.46	150	49	male
0.96	58 59	11	166	0.72	148	74	female
1.0	22 51	5.19	131	0.52	135	80	male
1.1	40 46	5.93	116	0.97	176	70	male
1.1	63 63	10.39	78	0.97	100	70	male
1.2	50 60	8.22	87	2.99	173	79	male
1.5	25 22	4.94	86	1.0	189	67	male
1.5	80 35	6.27	86	0.44	281	70	female

The data were analyzed as in Table I. The patients selected have arteriosclerosis.
These samples were contributed by the Southwest Kansas Medical Association, Coffeyville, Kansas.

Figure 4: Risk factors and ADMA comparison

The individuals listed all have active vascular disease, as assessed by carotid artery duplex scan. The values for 5 metabolic risk factors for vascular disease are presented in the table. The “ideal” normal range for Hcys is less than 5 - 8mM; the normal values for CRP for this age range is approximately 1; the normal value for ADMA is 0.4. The ages range from 49 to 86 years, and many have a family history of vascular disease. The average age of the men is 69.8 and the women is 63.7, and there is no significant difference in any of these values related to gender. The patients are listed from low to high ADMA values. The data from the % occlusion of the carotid vessels indicate that high ADMA levels correlate better with severity of vascular disease than any other risk factor measured. There are a few exceptions but these relate to the age of the patients, and the one rare individual with low risk factor values except for ADMA. The overall picture of the data indicate that ADMA is a much better predictor of risk for vascular disease and may be the one factor other than cholesterol that should be monitored. The abbreviation for blood sugar is BS. These data were obtained from Jerry Block, MD, a collaborator at the Southeast Kansas Medical Center in Coffeeville, Kansas.